The group, who have won three MOBOs, will play Plymouth Pavilions on April 14, 2010 as part of the Against All Odds tour.
N-Dubz, from Camden, have had three top 40 hits in the UK singles chart and a platinum-selling album.
The group's second album, also titled Against All Odds, went into the UK charts at number six last week.
Comprised of Dino 'Dappy' Contostavlos, Tula 'Tulisa' Contostavlos, and Richard 'Fazer' Rawson, N-Dubz originally met as schoolmates and began their recording career as the Lickle Rinsers Crew.
After changing their name to N-Dubz, the group began to experience modest chart success in 2006. But it wasn't until 2008 that the group hit the big time,, with hits such as Ouch, Papa Can You Hear Me and I Need You as well as collaborations with Tinchy Stryder, Pixie Lott, Chipmunk, Mr Hudson and Wiley.
N-Dubz's first tour sold out within days and five extra dates had to be added. Plymouth is one of just 16 dates across the UK.
Tickets will go on sale at 9am on Friday, December 4 from 0845 146 1460 and www.plymouthpavilions.com